Mechanism of Xianling Gubao Capsule in the Treatment of Steroid Induced Osteonecrosis of Femoral Head

This study aimed to obtain the main active components of Xianling Gubao capsule and identify their pharmacological characteristics mechanism action in treatment steroid-induced femoral head necrosis. The chemical constituents direct targets were obtained by system pharmacology platform traditional Chinese medicine. GeneCards database gene expression omnibus used pathogenic genes related Through Venn diagram software, intersection drug disease-related was potential capsule. In Cytoscape 3.7.1 component-target protein-protein interaction networks visualized analyzed network analyze plugin molecular complex detection plugin, degree values nodes screen core genes. Finally, for annotation, visualization integrated discovery enrichment analysis. We 76 Gubao, 583 necrosis 38 A componenttargets with 1001 3661 edges, a 31 67 edges constructed. 15 topology analysis showed that they mainly concentrated chemokine signaling pathway. 5 optimal obtained, respectively. can prevent or treat promoting reconstruction new capillaries after necrosis, improving intravascular coagulation, accelerating formation callus regulating differentiation direction bone marrow stem cells.